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CYP2U1 Antibody (aa281-330)

Rabbit Polyclonal Antibody

     
  • IHC - CYP2U1 Antibody (aa281-330) ALS16633
    Anti-CYP2U1 antibody IHC staining of human colon.
    detail
  • WB - CYP2U1 Antibody (aa281-330) ALS16633
    Western blot of extracts from HeLa/Lovo cells, using Cytochrome P450 2U1 Antibody.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q7Z449
Other Accession 113612
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 61987 Da
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 113612
Other Names CYP2U1, p450TEC, SPG49, Cytochrome P450 2U1
Target/Specificity Cytochrome P450 2U1 Antibody detects endogenous levels of total Cytochrome P450 2U1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsCYP2U1 Antibody (aa281-330) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP2U1 {ECO:0000303|PubMed:14660610, ECO:0000312|HGNC:HGNC:20582}
Function A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460). May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24563460).
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein
Tissue Location Widely expressed with stronger expression in thymus, heart and cerebellum.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes.

References

Chuang S.S.,et al.J. Biol. Chem. 279:6305-6314(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Karlgren M.,et al.Biochem. Biophys. Res. Commun. 315:679-685(2004).
Choudhary D.,et al.Arch. Biochem. Biophys. 436:50-61(2005).
Tesson C.,et al.Am. J. Hum. Genet. 91:1051-1064(2012).

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Discontinued
Cat# ALS16633
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