CYP2U1 Antibody (aa281-330)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, E |
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Primary Accession | Q7Z449 |
Other Accession | 113612 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 61987 Da |
Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
Gene ID | 113612 |
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Other Names | CYP2U1, p450TEC, SPG49, Cytochrome P450 2U1 |
Target/Specificity | Cytochrome P450 2U1 Antibody detects endogenous levels of total Cytochrome P450 2U1 protein. |
Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
Precautions | CYP2U1 Antibody (aa281-330) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CYP2U1 {ECO:0000303|PubMed:14660610, ECO:0000312|HGNC:HGNC:20582} |
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Function | A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460). May down-regulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24563460). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi- pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed with stronger expression in thymus, heart and cerebellum. |
Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes.
References
Chuang S.S.,et al.J. Biol. Chem. 279:6305-6314(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Karlgren M.,et al.Biochem. Biophys. Res. Commun. 315:679-685(2004).
Choudhary D.,et al.Arch. Biochem. Biophys. 436:50-61(2005).
Tesson C.,et al.Am. J. Hum. Genet. 91:1051-1064(2012).
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