|Application ||WB, IHC-P, IF, E|
|Calculated MW||48315 Da|
|Dilution||ELISA (1:40000), IF (1:100 - 1:500), IHC-P (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||ABHD2, HS1-2, Lung alpha/beta hydrolase 2, PHPS1-2, LABH2, Protein PHPS1-2|
|Target/Specificity||ABHD2 Antibody detects endogenous levels of total ABHD2 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||ABHD2 Antibody (aa251-300) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).|
|Cellular Location||Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Present in sperm (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
May play a role in smooth muscle cells migration.
Rapiejko P.J.,et al.Nucleic Acids Res. 16:8721-8721(1988).
Utleg A.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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