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ABHD2 Antibody (aa251-300)

Rabbit Polyclonal Antibody

     
  • IHC - ABHD2 Antibody (aa251-300) ALS16641
    Anti-ABHD2 antibody IHC staining of human testis.
  • IF - ABHD2 Antibody (aa251-300) ALS16641
    Immunofluorescence of MCF-7 cells, using ABHD2 Antibody.
  • WB - ABHD2 Antibody (aa251-300) ALS16641
    Western blot of extracts from HT29 cells, using ABHD2 Antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P08910
Other Accession 11057
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 48315 Da
Dilution ELISA (1:40000), IF (1:100 - 1:500), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 11057
Other Names ABHD2, HS1-2, Lung alpha/beta hydrolase 2, PHPS1-2, LABH2, Protein PHPS1-2
Target/Specificity ABHD2 Antibody detects endogenous levels of total ABHD2 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsABHD2 Antibody (aa251-300) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ABHD2 (HGNC:18717)
Function Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).
Cellular Location Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein
Tissue Location Present in sperm (at protein level).
Volume 50 µl
Citations (0)

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Background

May play a role in smooth muscle cells migration.

References

Rapiejko P.J.,et al.Nucleic Acids Res. 16:8721-8721(1988).
Utleg A.,et al.Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16641
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