|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||40514 Da|
|Dilution||ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||DNAJB11, ABBP-2, ABBP2, APOBEC1-binding protein 2, DJ9, DnaJ protein 9, DnaJ protein homolog 9, EDJ, ERj3, ERj3p, HDJ9, ER-associated dnaJ protein 3, Human DnaJ protein 9, HDj-9, HEDJ, UNQ537, Dj-9, ER-associated DNAJ, ERdj3, PRO1080|
|Target/Specificity||DNAJB11 Antibody detects endogenous levels of total DNAJB11 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||DNAJB11 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||EDJ, ERJ3, HDJ9|
|Function||Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.|
|Cellular Location||Endoplasmic reticulum lumen Note=Associated with the ER membrane in a C-terminally epitope- tagged construct|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.
Ohtsuka K.,et al.Cell Stress Chaperones 5:98-112(2000).
Yu M.,et al.J. Biol. Chem. 275:24984-24992(2000).
Bies C.,et al.Biol. Chem. 385:389-395(2004).
Honore B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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