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DNAJB11 Antibody (aa31-80)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UBS4 |
| Other Accession | 51726 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 40514 Da |
| Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 51726 |
|---|---|
| Other Names | DNAJB11, ABBP-2, ABBP2, APOBEC1-binding protein 2, DJ9, DnaJ protein 9, DnaJ protein homolog 9, EDJ, ERj3, ERj3p, HDJ9, ER-associated dnaJ protein 3, Human DnaJ protein 9, HDj-9, HEDJ, UNQ537, Dj-9, ER-associated DNAJ, ERdj3, PRO1080 |
| Target/Specificity | DNAJB11 Antibody detects endogenous levels of total DNAJB11 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | DNAJB11 Antibody (aa31-80) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAJB11 |
|---|---|
| Synonyms | EDJ, ERJ3, HDJ9 |
| Function | As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). |
| Cellular Location | Endoplasmic reticulum lumen Note=Associated with the ER membrane in a C-terminally epitope-tagged construct |
| Tissue Location | Widely expressed. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity.
References
Ohtsuka K.,et al.Cell Stress Chaperones 5:98-112(2000).
Yu M.,et al.J. Biol. Chem. 275:24984-24992(2000).
Bies C.,et al.Biol. Chem. 385:389-395(2004).
Honore B.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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