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CAV1 / Caveolin 1 Antibody (N-Terminus)

Goat Polyclonal Antibody

     
  • IHC - CAV1 / Caveolin 1 Antibody (N-Terminus) ALS16653
    Anti-CAV1 / Caveolin 1 antibody IHC staining of human heart.
    detail
  • IF - CAV1 / Caveolin 1 Antibody (N-Terminus) ALS16653
    Immunofluorescence - anti-CAV1 antibody - Caveolae Marker in Hepa1-6 cells at 1:50 dilution.
    detail
  • WB - CAV1 / Caveolin 1 Antibody (N-Terminus) ALS16653
    Western blot.
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession Q03135
Other Accession 857
Reactivity Human, Mouse, Dog
Host Goat
Clonality Polyclonal
Isotype IgG
Calculated MW 20472 Da
Dilution IF (1:25 - 1:250), IHC-P (5 µg/ml), WB (1:500 - 1:2000),
Additional Information
Gene ID 857
Other Names CAV1, Caveolin-1, CGL3, CAV, MSTP085, VIP21, BSCL3
Target/Specificity Detects a band of approximately 25 kDa by Western blot in the following cell lysate: hCat, MDCK and 3T3.
Reconstitution & Storage PBS, 20% glycerol, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsCAV1 / Caveolin 1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CAV1
Synonyms CAV
Function May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
Cellular Location Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P33724} Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae
Tissue Location Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain
Volume 100 µl
Research Areas
Citations (0)
citation

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Background

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

References

Glenney J.R. Jr.,et al.FEBS Lett. 314:45-48(1992).
Hurlstone A.F.,et al.Oncogene 18:1881-1890(1999).
Engelman J.A.,et al.FEBS Lett. 448:221-230(1999).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Vainonen J.P.,et al.Biochem. Biophys. Res. Commun. 320:480-486(2004).

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$ 467.50
Cat# ALS16653
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