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GRG4 / TLE4 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GRG4 / TLE4 Antibody (N-Terminus) ALS16655
    Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
    detail
  • WB - GRG4 / TLE4 Antibody (N-Terminus) ALS16655
    Western Blot analysis of HEK293 cell lysates with anti-TLE4 antibody
    detail
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
  • detail
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q04727
Other Accession 7091
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 83755 Da
Dilution ELISA (1:1000 - 1:10000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 7091
Other Names TLE4, BCE1, BCE-1, E(spI), Enhancer of split groucho 4, ESG, ESG4, GRG4, Protein BCE-1, KIAA1261, R-esp2, B lymphocyte gene 1
Target/Specificity The peptide sequence of this antibody is corresponding to amino acids of human 1-50aa. This antibody is predicted to recognize mouse and rat TLE4 protein because of synthesized peptide amino acid 100% homology with mouse and rattus TLE4 protein.
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.
PrecautionsGRG4 / TLE4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLE4
Synonyms GRG4, KIAA1261
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity).
Cellular Location Nucleus.
Tissue Location In all tissues examined, mostly in brain, and muscle
Volume 100 µl
Research Areas
Citations (0)
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Background

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

References

Nagase T.,et al.DNA Res. 6:337-345(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Humphray S.J.,et al.Nature 429:369-374(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Stifani S.,et al.Nat. Genet. 2:119-127(1992).

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Discontinued
Cat# ALS16655
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