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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RAB1A Antibody (C-Terminus)   

RAB1A Antibody (C-Terminus)

Goat Polyclonal Antibody

     
  • IHC - RAB1A Antibody (C-Terminus) ALS16657
    Anti-RAB1A / RAB1 antibody IHC staining of human small intestine.
  • IHC - RAB1A Antibody (C-Terminus) ALS16657
    Anti-RAB1A / RAB1 antibody IHC staining of human kidney.
  • IF - RAB1A Antibody (C-Terminus) ALS16657
    Immunofluorescence - anti-Rab1 antibody in COS-7 cells at 1:50 dilution.
  • WB - RAB1A Antibody (C-Terminus) ALS16657
    Western blot.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P62820
Other Accession 5861
Reactivity Human, Mouse, Rat, Monkey
Host Goat
Clonality Polyclonal
Isotype IgG
Calculated MW 22678 Da
Dilution IF (1:100 - 1:250), IHC-P (5 µg/ml), WB (1:250 - 1:2000),
Additional Information
Gene ID 5861
Other Names RAB1A, GTP binding protein Rab1a, YPT1-related protein, Rab GTPase YPT1 homolog, RAB1, Ras-related protein Rab-1A, YPT1
Target/Specificity Detects total Rab1 protein by Western blot in the following human, rat and mouse whole cell lysates and transfected cells with GFP-Rab1a and GFP-Rab1b cds.
Reconstitution & Storage PBS, 20% glycerol, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PrecautionsRAB1A Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB1A
Synonyms RAB1
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Cellular Location Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome. Note=Alternates between membrane-associated and cytosolic forms
Volume 50 µl
Research Areas
Citations (0)

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Background

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

References

Zahraoui A.,et al.J. Biol. Chem. 264:12394-12401(1989).
Wiemann S.,et al.Genome Res. 11:422-435(2001).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16657
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