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BTLA / CD272 Antibody (clone 4C2)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q7Z6A9 |
| Other Accession | 151888 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b |
| Clone Names | 4C2 |
| Calculated MW | 32834 Da |
| Dilution | IHC-P (10 µg/ml), WB (1:2000), |
| Gene ID | 151888 |
|---|---|
| Other Names | BTLA, BTLA1, B and T lymphocyte associated, CD272, B and T lymphocyte attenuator, B- and T-lymphocyte attenuator, CD272 antigen |
| Target/Specificity | Human BTLA |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | BTLA / CD272 Antibody (clone 4C2) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BTLA {ECO:0000303|PubMed:12796776, ECO:0000312|HGNC:HGNC:21087} |
|---|---|
| Function | Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006, PubMed:15568026, PubMed:18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.
References
Watanabe N.,et al.Nat. Immunol. 4:670-679(2003).
Mao Y.,et al.Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Oaks M.K.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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