|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||77752 Da|
|Dilution||ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||ACSL6, ACS2, FACL6, LACS 6, LACS2, KIAA0837, LACS5|
|Target/Specificity||ACSL6 Antibody detects endogenous levels of total ACSL6 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||ACSL6 Antibody (aa499-548) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACS2, FACL6, KIAA0837, LACS5|
|Function||Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.|
|Cellular Location||Mitochondrion outer membrane; Single-pass type III membrane protein. Peroxisome membrane; Single-pass type III membrane protein. Microsome membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein|
|Tissue Location||Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.|
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Provided below are standard protocols that you may find useful for product applications.
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Malhotra K.T.,et al.Biochem. J. 344:135-143(1999).
Yagasaki F.,et al.Genes Chromosomes Cancer 26:192-202(1999).
Soupene E.,et al.BMC Mol. Biol. 7:21-21(2006).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Li W.B.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
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