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CHRNA10 Antibody (aa394-443)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9GZZ6 |
| Other Accession | 57053 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 49705 Da |
| Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 57053 |
|---|---|
| Other Names | CHRNA10, AChR-alpha10, NACHRA10, NACHR alpha-10 |
| Target/Specificity | CHRNA10 Antibody detects endogenous levels of total CHRNA10 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | CHRNA10 Antibody (aa394-443) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CHRNA10 |
|---|---|
| Synonyms | NACHRA10 |
| Function | Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. |
| Cellular Location | Postsynaptic cell membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
References
Sgard F.,et al.Mol. Pharmacol. 61:150-159(2002).
Lustig L.R.,et al.Genomics 73:272-283(2001).
Vandenberk I.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Peng H.,et al.Life Sci. 76:263-280(2004).
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