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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CHRNA10 Antibody (aa394-443)   

CHRNA10 Antibody (aa394-443)

Rabbit Polyclonal Antibody

     
  • IHC - CHRNA10 Antibody (aa394-443) ALS16674
    Anti-CHRNA10 antibody IHC staining of human brain, cerebellum.
  • WB - CHRNA10 Antibody (aa394-443) ALS16674
    Western blot of extracts from HeLa/293/COLO/A549 cells, using CHRNA10 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9GZZ6
Other Accession 57053
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 49705 Da
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 57053
Other Names CHRNA10, AChR-alpha10, NACHRA10, NACHR alpha-10
Target/Specificity CHRNA10 Antibody detects endogenous levels of total CHRNA10 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsCHRNA10 Antibody (aa394-443) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHRNA10
Synonyms NACHRA10
Function Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
Volume 50 µl
Research Areas
Citations (0)

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Background

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

References

Sgard F.,et al.Mol. Pharmacol. 61:150-159(2002).
Lustig L.R.,et al.Genomics 73:272-283(2001).
Vandenberk I.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
Peng H.,et al.Life Sci. 76:263-280(2004).

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$ 395.00
Cat# ALS16674
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