|Application ||WB, IHC, E|
|Calculated MW||71928 Da|
|Dilution||ELISA (1:40000), IHC (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||RAB11FIP4, FIP4-Rab11, KIAA1821, ARFO2, Arfophilin-2, RAB11-FIP4|
|Target/Specificity||RAB11FIP4 Antibody detects endogenous levels of total RAB11FIP4 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||RAB11FIP4 / RAB11-FIP4 Antibody (aa452-501) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.|
|Cellular Location||Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle Note=Recruited to the cleavage furrow and the midbody during cytokinesis|
|Tissue Location||Present at high level in testis (at protein level). Weakly expressed in other tissues|
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Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
Wallace D.M.,et al.Biochem. Biophys. Res. Commun. 299:770-779(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Jenne D.E.,et al.Genes Chromosomes Cancer 37:111-120(2003).
Nagase T.,et al.DNA Res. 8:85-95(2001).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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