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TLK1 Antibody (aa730-779)

Rabbit Polyclonal Antibody

     
  • IHC - TLK1 Antibody (aa730-779) ALS16679
    Anti-TLK1 antibody IHC staining of human placenta.
  • IF - TLK1 Antibody (aa730-779) ALS16679
    Immunofluorescence of COS7 cells, using TLK1 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, E
Primary Accession Q9UKI8
Other Accession 9874
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 86700 Da
Dilution ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 µg/ml),
Additional Information
Gene ID 9874
Other Names TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK
Target/Specificity TLK1 Antibody detects endogenous levels of total TLK1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsTLK1 Antibody (aa730-779) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLK1
Synonyms KIAA0137
Function Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Cellular Location Nucleus
Tissue Location Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.
Volume 50 µl
Research Areas
Citations (0)

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Background

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

References

Yamakawa A.,et al.Gene 202:193-201(1997).
Sillje H.H.W.,et al.EMBO J. 18:5691-5702(1999).
Cabaniols J.-P.,et al.Mol. Biol. Cell 10:4033-4041(1999).
Nagase T.,et al.DNA Res. 2:167-174(1995).
Nakajima D.,et al.DNA Res. 9:99-106(2002).

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$ 395.00
Cat# ALS16679
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