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TLK1 Antibody (aa730-779)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IF, E |
|---|---|
| Primary Accession | Q9UKI8 |
| Other Accession | 9874 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 86700 Da |
| Dilution | ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 µg/ml), |
| Gene ID | 9874 |
|---|---|
| Other Names | TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK |
| Target/Specificity | TLK1 Antibody detects endogenous levels of total TLK1 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | TLK1 Antibody (aa730-779) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLK1 |
|---|---|
| Synonyms | KIAA0137 |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| Cellular Location | Nucleus |
| Tissue Location | Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
References
Yamakawa A.,et al.Gene 202:193-201(1997).
Sillje H.H.W.,et al.EMBO J. 18:5691-5702(1999).
Cabaniols J.-P.,et al.Mol. Biol. Cell 10:4033-4041(1999).
Nagase T.,et al.DNA Res. 2:167-174(1995).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
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