|Application ||WB, IHC-P, E|
|Calculated MW||20745 Da|
|Dilution||ELISA (1:10000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||RAP2C, Ras-related protein Rap-2c, Small GTPase RAP2C|
|Target/Specificity||RAP2C Antibody detects endogenous levels of total RAP2C protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||RAP2C Antibody (aa97-146) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.|
|Cellular Location||Cytoplasm. Recycling endosome membrane; Lipid-anchor; Cytoplasmic side|
|Tissue Location||Expressed in liver, skeletal muscle, prostate, uterus, rectum, stomach, and bladder and to a lower extent in brain, kidney, pancreas, and bone marrow. Expressed in mononuclear leukocytes and megakaryocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.
Guo Z.,et al.Mol. Biol. Rep. 34:137-144(2007).
Rhodes S.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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