|Application ||WB, IHC-P, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27213 Da|
|Dilution||ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),|
|Other Names||OTUB2, C14orf137, Deubiquitinating enzyme OTUB2, OTU2, Ubiquitin thioesterase OTUB2, OTB2, Otubain-2|
|Target/Specificity||OTUB2 Antibody detects endogenous levels of total OTUB2 protein.|
|Reconstitution & Storage||PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.|
|Precautions||OTUB2 Antibody (aa133-182) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C14orf137, OTB2, OTU2|
|Function||Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'- linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.|
|Tissue Location||Widely expressed. Expressed at higher level in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'- linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Balakirev M.Y.,et al.EMBO Rep. 4:517-522(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Heilig R.,et al.Nature 421:601-607(2003).
Edelmann M.J.,et al.Biochem. J. 418:379-390(2009).
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