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CD44 Antibody (clone IM7, PE, Cy7)

Rat Monoclonal Antibody

     
  • IHC - CD44 Antibody (clone IM7, PE, Cy7) ALS16696
    Anti-CD44 antibody IHC staining of human spleen.
  • FC - CD44 Antibody (clone IM7, PE, Cy7) ALS16696
    Staining of C57Bl/6 splenocytes with 0.06 ug of PE-Cy7 Rat IgG2b isotype control (open...
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, Flo
Primary Accession P16070
Other Accession 960
Reactivity Human, Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2b,k
Clone Names IM7
Calculated MW 81538 Da
Dilution IHC-P (1:50),
Additional Information
Gene ID 960
Other Names CD44, CDW44, CD44 antigen, Cell surface glycoprotein CD44, CSPG8, ECMR-III, Epican, HUTCH-I, LHR, MDU2, MC56, MIC4, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, PGP-1, PGP-I, Pgp1, Phagocytic glycoprotein I, MDU3, CD44R, HCELL, He ...
Reconstitution & Storage Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer. Store at +4°C. Do not freeze. Product is photosensitive and should be protected from light.
PrecautionsCD44 Antibody (clone IM7, PE, Cy7) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD44
Synonyms LHR, MDU2, MDU3, MIC4
Function Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P15379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15379}. Note=Colocalizes with actin in membrane protrusions at wounding edges {ECO:0000250|UniProtKB:P15379}
Tissue Location Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas Expression is repressed in neuroblastoma cells
Research Areas
Citations (0)

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Background

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

References

Stamenkovic I.,et al.Cell 56:1057-1062(1989).
Harn H.-J.,et al.Biochem. Biophys. Res. Commun. 178:1127-1134(1991).
Stamenkovic I.,et al.EMBO J. 10:343-348(1991).
Dougherty G.J.,et al.J. Exp. Med. 174:1-5(1991).
Kugelman L.C.,et al.J. Invest. Dermatol. 99:886-891(1992).

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$ 395.00
Cat# ALS16696
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