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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   CENPU / MLF1IP Antibody   

CENPU / MLF1IP Antibody

Rabbit Polyclonal Antibody

     
  • IHC - CENPU / MLF1IP Antibody ALS16703
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • ICC - CENPU / MLF1IP Antibody ALS16703
    Immunocytochemistry: Anti-CENP-50
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC
Primary Accession Q71F23
Other Accession 79682
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 47522 Da
Dilution ICC (1:1000), IHC-P (1:100),
Additional Information
Gene ID 79682
Other Names CENPU, CENP-U, CENP50, CENPU50, Centromere protein U, ICEN24, KLIP1, Polo-box-interacting protein 1, MLF1-interacting protein, CENP-50, Centromere protein of 50 kDa, MLF1 interacting protein, MLF1IP, PBIP1
Target/Specificity Human MLF1IP / CENP-U
Reconstitution & Storage PBS, pH 7.2, 50% glycerol. Store at -20°C.
PrecautionsCENPU / MLF1IP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CENPU
Synonyms ICEN24, KLIP1, MLF1IP, PBIP1
Function Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.
Cellular Location Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates
Tissue Location Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells Expressed at high levels in glioblastoma cell lines
Volume 500 µl
Research Areas
Citations (0)

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Background

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

References

Pan H.-Y.,et al.J. Virol. 77:9758-9768(2003).
Hanissian S.H.,et al.Oncogene 23:3700-3707(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Hanissian S.H.,et al.Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16703
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