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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   DAPK2 / DAP Kinase 2 Antibody (clone 1B5)   

DAPK2 / DAP Kinase 2 Antibody (clone 1B5)

Mouse Monoclonal Antibody

     
  • IHC - DAPK2 / DAP Kinase 2 Antibody (clone 1B5) ALS16708
    Anti-DAPK2 / DRP1 antibody IHC staining of human heart.
  • IF - DAPK2 / DAP Kinase 2 Antibody (clone 1B5) ALS16708
    Anti-DAPK2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently...
  • WB - DAPK2 / DAP Kinase 2 Antibody (clone 1B5) ALS16708
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DAPK2...
  •  - DAPK2 / DAP Kinase 2 Antibody (clone 1B5) ALS16708
    Immunoprecipitation(IP) of DAPK2 by using monoclonal anti-DAPK2 antibodies (Negative control: IP...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP
Primary Accession Q9UIK4
Other Accession 23604
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 1B5
Calculated MW 42898 Da
Dilution IF (1:100), IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Gene ID 23604
Other Names DAPK2, DAP-kinase-related protein 1, DRP-1, DRP1, DAP kinase 2
Target/Specificity Human DAPK2
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsDAPK2 / DAP Kinase 2 Antibody (clone 1B5) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DAPK2
Function Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).
Cellular Location Cytoplasm. Cytoplasmic vesicle, autophagosome lumen
Tissue Location Expressed in neutrophils and eosinophils (PubMed:24163421). Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle.
Volume 50 µl
Research Areas
Citations (0)

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Background

Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation.

References

Kawai T.,et al.Oncogene 18:3471-3480(1999).
Inbal B.,et al.Mol. Cell. Biol. 20:1044-1054(2000).
Shoval Y.,et al.PLoS ONE 6:E17344-E17344(2011).
Zody M.C.,et al.Nature 440:671-675(2006).
Shani G.,et al.EMBO J. 20:1099-1113(2001).

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$ 395.00
Cat# ALS16708
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