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ALPK1 Antibody (aa11-60)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q96QP1 |
| Other Accession | 80216 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 138861 Da |
| Dilution | ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 80216 |
|---|---|
| Other Names | ALPK1, Alpha-protein kinase 1, Chromosome 4 kinase, LAK, Lymphocyte alpha-kinase, KIAA1527, Alpha-kinase 1 |
| Target/Specificity | ALPK1 Antibody detects endogenous levels of total ALPK1 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | ALPK1 Antibody (aa11-60) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALPK1 {ECO:0000303|PubMed:30111836, ECO:0000312|HGNC:HGNC:20917} |
|---|---|
| Function | Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta- D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram- negative and some Gram-positive bacteria (PubMed:30111836). ADP- Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). May play a role in ciliogenesis (PubMed:30967659). |
| Cellular Location | Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Note=Localized at the base of primary cilia. |
| Tissue Location | Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina (PubMed:30967659) |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.
References
Ryazanov A.G.,et al.Curr. Biol. 9:R43-R45(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Jikuya H.,et al.Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 7:143-150(2000).
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