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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   CD68 Antibody (clone KP1)   

CD68 Antibody (clone KP1)

Mouse Monoclonal Antibody

     
  • IHC - CD68 Antibody (clone KP1) ALS16716
    Anti-CD68 antibody IHC staining of human lung.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, IP, Flo
Primary Accession P34810
Other Accession 968
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names KP1
Calculated MW 37408 Da
Dilution IHC-P (5 µg/ml),
Additional Information
Gene ID 968
Other Names CD68, CD68 antigen, gp110, SCARD1, CD68 molecule, LAMP4, Macrophage antigen CD68, Macrosialin
Target/Specificity Recognizes the human CD68 cell surface antigen, a 110kD glycoprotein primarily expressed by macrophages and monocytes.
Reconstitution & Storage PBS, 0.09% sodium azide. +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsCD68 Antibody (clone KP1) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD68
Function Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Cellular Location Isoform Short: Cell membrane; Single-pass type I membrane protein
Tissue Location Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites
Research Areas
Citations (0)

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Background

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

References

Holness C.L.,et al.Blood 81:1607-1613(1993).
Kalnine N.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:1045-1049(2006).

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$ 395.00
Cat# ALS16716
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