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CLK4 Antibody (aa101-150)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9HAZ1 |
| Other Accession | 57396 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 57492 Da |
| Dilution | ELISA (1:1000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 57396 |
|---|---|
| Other Names | CLK4, CDC-like kinase 4 |
| Target/Specificity | CLK4 Antibody detects endogenous levels of total CLK4 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | CLK4 Antibody (aa101-150) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CLK4 |
|---|---|
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in liver, kidney, heart, muscle, brain and endothelial cells. |
| Volume | 50 µl |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
References
Schultz J.,et al.Genomics 71:368-370(2001).
Schultz J.,et al.Genomics 74:251-251(2001).
McNally T.,et al.Protein Sci. 12:1562-1566(2003).
Kantham L.,et al.Biochem. Biophys. Res. Commun. 304:125-129(2003).
Olsen J.V.,et al.Cell 127:635-648(2006).
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