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BRMS1 Antibody (aa21-70)

Rabbit Polyclonal Antibody

     
  • IHC - BRMS1 Antibody (aa21-70) ALS16724
    Anti-BRMS1 antibody IHC staining of human testis.
  • WB - BRMS1 Antibody (aa21-70) ALS16724
    Western blot of extracts from 293 cells, using BRMS1 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9HCU9
Other Accession 25855
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 28461 Da
Dilution ELISA (1:20000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 25855
Other Names BRMS1, DKFZP564A063
Target/Specificity BRMS1 Antibody detects endogenous levels of total BRMS1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsBRMS1 Antibody (aa21-70) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRMS1
Function Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Cellular Location Nucleus. Cytoplasm. Note=Predominantly nuclear
Tissue Location Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies
Volume 50 µl
Citations (0)

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Background

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

References

Seraj M.J.,et al.Cancer Res. 60:2764-2769(2000).
Welch D.R.,et al.Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Janneau J.-L.,et al.J. Clin. Endocrinol. Metab. 87:5336-5339(2002).

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$ 395.00
Cat# ALS16724
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