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Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q08828 |
| Other Accession | 107 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 123440 Da |
| Dilution | ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500 - 1:1000), |
| Gene ID | 107 |
|---|---|
| Other Names | ADCY1, 3, 5-cyclic AMP synthetase, Adenylate cyclase type I, AC1, Adenylate cyclase type 1, Adenylyl cyclase 1, ATP pyrophosphate-lyase 1, Adenyl cyclase, Adenylate cyclase 1 (brain), Adenylate cyclase, type i, ATP pyrophosphate-lyase |
| Target/Specificity | ADCY1 Antibody detects endogenous levels of total ADCY1 protein. |
| Reconstitution & Storage | PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year. |
| Precautions | ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADCY1 |
|---|---|
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:P19754}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19754}. Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O88444} Membrane raft {ECO:0000250|UniProtKB:P19754}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444} |
| Tissue Location | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
References
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Villacres E.C.,et al.Genomics 16:473-478(1993).
Santos-Cortez R.L.,et al.Hum. Mol. Genet. 23:3289-3298(2014).
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