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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280)   

ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280)

Rabbit Polyclonal Antibody

     
  • IHC - ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) ALS16725
    Huma Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) ALS16725
    Anti-ADCY1 / Adenylate Cyclase 1 antibody IHC staining of human brain, cortex.
  • WB - ADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) ALS16725
    Western blot of extracts from COLO205 cells, using ADCY1 Antibody.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q08828
Other Accession 107
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 123440 Da
Dilution ELISA (1:40000), IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 107
Other Names ADCY1, 3, 5-cyclic AMP synthetase, Adenylate cyclase type I, AC1, Adenylate cyclase type 1, Adenylyl cyclase 1, ATP pyrophosphate-lyase 1, Adenyl cyclase, Adenylate cyclase 1 (brain), Adenylate cyclase, type i, ATP pyrophosphate-lyase
Target/Specificity ADCY1 Antibody detects endogenous levels of total ADCY1 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsADCY1 / Adenylate Cyclase 1 Antibody (aa231-280) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADCY1
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
Cellular Location Membrane {ECO:0000250|UniProtKB:P19754}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19754}. Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:O88444} Membrane raft {ECO:0000250|UniProtKB:P19754}. Note=Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. {ECO:0000250|UniProtKB:O88444}
Tissue Location Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla
Volume 50 µl
Research Areas
Citations (0)

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Background

This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).

References

Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
Villacres E.C.,et al.Genomics 16:473-478(1993).
Santos-Cortez R.L.,et al.Hum. Mol. Genet. 23:3289-3298(2014).

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$ 395.00
Cat# ALS16725
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