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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   MAGEA3 Antibody (clone 4E2)   

MAGEA3 Antibody (clone 4E2)

Mouse Monoclonal Antibody

     
  • IHC-P - MAGEA3 Antibody (clone 4E2) ALS16729
    Anti-MAGEA3 antibody IHC staining of human testis.
  • WB - MAGEA3 Antibody (clone 4E2) ALS16729
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MAGEA3...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P43357
Other Accession 4102
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 4E2
Calculated MW 34747 Da
Dilution IHC-P (10 µg/ml), WB (1:2000),
Additional Information
Gene ID 4102
Other Names MAGEA3, Antigen MZ2-D, Cancer/testis antigen 1.3, CT1.3, HYPD, MAGE-3 antigen, Melanoma-associated antigen 3, HIP8, MAGE3, Melanoma antigen family A, 3
Target/Specificity Human MAGEA3
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsMAGEA3 Antibody (clone 4E2) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAGEA3
Synonyms MAGE3
Function Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Tissue Location Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, Leukemias and lymphomas
Volume 50 µl
Research Areas
Citations (0)

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Background

Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

References

Gaugler B.,et al.J. Exp. Med. 179:921-930(1994).
Ding M.,et al.Biochem. Biophys. Res. Commun. 202:549-555(1994).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mallon A.-M.,et al.Genome Res. 10:758-775(2000).

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$ 395.00
Cat# ALS16729
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