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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HSPG2 / Perlecan Antibody (clone A7L6)   

HSPG2 / Perlecan Antibody (clone A7L6)

Rat Monoclonal Antibody

     
  • IHC - HSPG2 / Perlecan Antibody (clone A7L6) ALS16735
    IHC with HSPG2 antibody on frozen human spleen.
  • IHC - HSPG2 / Perlecan Antibody (clone A7L6) ALS16735
    IHC with HSPG2 antibody on frozen human kidney.
  • IHC - HSPG2 / Perlecan Antibody (clone A7L6) ALS16735
    IHC with HSPG2 antibody on frozen human heart.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, ICC, IP, IHC-Fr
Primary Accession P98160
Other Accession 3339
Reactivity Human, Mouse, Rat, Bovine
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names A7L6
Calculated MW 468830 Da
Dilution IHC-Fr (1:50), IP (1:100 - 1:1000),
Additional Information
Gene ID 3339
Other Names HSPG2, Endorepellin (domain V region), HSPG, Heparan sulfate proteoglycan 2, Perlecan, Perlecan proteoglycan, SJA, SJS1, PRCAN, SJS
Target/Specificity Recognizes domain IV of the core protein of the large heparan sulphate proteoglycan or perlecan. The reactivity is independent of the galactosaminoglycan moieties. Therefore, the epitope is not sensitive to heparitinase treatment.
Reconstitution & Storage PBS containing 0.09% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsHSPG2 / Perlecan Antibody (clone A7L6) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSPG2
Function Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.
Cellular Location Secreted, extracellular space, extracellular matrix, basement membrane
Tissue Location Found in the basement membranes.
Research Areas
Citations (0)

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Background

Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

References

Murdoch A.D.,et al.J. Biol. Chem. 267:8544-8557(1992).
Kallunki P.,et al.J. Cell Biol. 116:559-571(1992).
Gregory S.G.,et al.Nature 441:315-321(2006).
Cohen I.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:10404-10408(1993).
Nicole S.,et al.Nat. Genet. 26:480-483(2000).

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$ 395.00
Cat# ALS16735
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