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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TSC22D3 / GILZ Antibody (N-Terminus)   

TSC22D3 / GILZ Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - TSC22D3 / GILZ Antibody (N-Terminus) ALS16745
    Anti-TSC22D3 / GILZ antibody IHC staining of human lung.
  • IF - TSC22D3 / GILZ Antibody (N-Terminus) ALS16745
    Immunofluorescence of TSC22D3 in human small intestine tissue with TSC22D3 antibody at 20 ug/ml.
  • WB - TSC22D3 / GILZ Antibody (N-Terminus) ALS16745
    Western blot analysis of TSC22D3 in human small intestine tissue lysate with TSC22D3 antibody at...
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q99576
Other Accession 1831
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 14810 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 1831
Other Names TSC22D3, DSIPI, DIP, DSIP-immunoreactive peptide, GILZ, TSC-22 related protein, Protein DIP, TSC22 domain family protein 3, HDIP, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22 domain family, member 3
Target/Specificity Human TSC22D3 / GILZ
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTSC22D3 / GILZ Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSC22D3
Synonyms DSIPI, GILZ
Function Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).
Cellular Location Isoform 1: Cytoplasm. Nucleus. Note=Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).
Tissue Location Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down- regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
Research Areas
Citations (0)

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Background

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti- myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

References

Vogel P.,et al.Biochim. Biophys. Acta 1309:200-204(1996).
Cannarile L.,et al.Cell Death Differ. 8:201-203(2001).
Wistow G.J.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Okada T.,et al.Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
Kim M.K.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16745
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