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>   home   >   Products   >   Primary Antibodies   >   PTRF / CAVIN Antibody (C-Terminus)   

PTRF / CAVIN Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - PTRF / CAVIN Antibody (C-Terminus) ALS16751
    Anti-PTRF / CAVIN antibody IHC staining of human spleen.
  • IF - PTRF / CAVIN Antibody (C-Terminus) ALS16751
    Immunofluorescence of PTRF in human spleen tissue with PTRF antibody at 20 ug/ml.
  • WB - PTRF / CAVIN Antibody (C-Terminus) ALS16751
    Western blot analysis of PTRF in human spleen tissue lysate with PTRF antibody at (A) 0.5 and...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q6NZI2
Other Accession 284119
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 43476 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml),
Additional Information
Gene ID 284119
Other Names PTRF, Cavin-1, CAVIN1, CAVIN, CGL4, FKSG13, TTF-I interacting peptide 12
Target/Specificity At least three isoforms of PTRF are known to exist; this antibody detects all three isoforms. It is predicted to not cross-react with other members of the cavin family.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsPTRF / CAVIN Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTRF {ECO:0000312|EMBL:AAH66123.1}
Function Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.
Cellular Location Membrane, caveola. Cell membrane Microsome. Endoplasmic reticulum {ECO:0000250|UniProtKB:P85125}. Cytoplasm, cytosol. Mitochondrion Nucleus. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane. Colocalizes with CAV1 in lipid rafts in adipocytes
Citations (0)

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Background

Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex.

References

Wang Y.-G.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Jansa P.,et al.EMBO J. 17:2855-2864(1998).
Aboulaich N.,et al.Biochem. J. 383:237-248(2004).

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$ 395.00
Cat# ALS16751
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