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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GBP5 Antibody (C-Terminus)   

GBP5 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GBP5 Antibody (C-Terminus) ALS16758
    Immunohistochemistry of GBP5 in human liver tissue with GBP5 antibody at 2.5 ug/ml.
  • IHC - GBP5 Antibody (C-Terminus) ALS16758
    Anti-GBP5 antibody IHC staining of human thymus.
  • IHC - GBP5 Antibody (C-Terminus) ALS16758
    Anti-GBP5 antibody IHC staining of human tonsil.
  • IF - GBP5 Antibody (C-Terminus) ALS16758
    Immunofluorescence of GBP5 in human liver tissue with GBP5 antibody at 20 ug/ml.
  • WB - GBP5 Antibody (C-Terminus) ALS16758
    Western blot analysis of GBP5 in rat liver tissue lysate with GBP5 antibody at 1 ug/ml in (A)...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q96PP8
Other Accession 115362
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 66617 Da
Dilution IHC-P (10 µg/ml), WB (1 µg/ml), WB (1 µg/ml),
Additional Information
Gene ID 115362
Other Names GBP5, GBP-TA antigen, GTP-binding protein 5, Guanylate binding protein 5, Guanylate-binding protein 5, GBP-5
Target/Specificity GBP5 antibody is predicted to not cross-react with other GBP family members.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGBP5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GBP5
Function As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
Cellular Location Cytoplasm. Golgi apparatus membrane; Lipid- anchor
Tissue Location Expressed in peripheral blood monocytes (at protein level).
Research Areas
Citations (0)

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Background

Stimulates the NLRP3 inflammasome assembly upon bacterial challenge.

References

Avdalovic A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Fellenberg F.,et al.J. Invest. Dermatol. 122:1510-1517(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16758
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