|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||66617 Da|
|Dilution||IHC-P (10 µg/ml), WB (1 µg/ml), WB (1 µg/ml),|
|Other Names||GBP5, GBP-TA antigen, GTP-binding protein 5, Guanylate binding protein 5, Guanylate-binding protein 5, GBP-5|
|Target/Specificity||GBP5 antibody is predicted to not cross-react with other GBP family members.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||GBP5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Lipid- anchor|
|Tissue Location||Expressed in peripheral blood monocytes (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Stimulates the NLRP3 inflammasome assembly upon bacterial challenge.
Avdalovic A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Fellenberg F.,et al.J. Invest. Dermatol. 122:1510-1517(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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