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GBP5 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q96PP8 |
| Other Accession | 115362 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 66617 Da |
| Dilution | IHC-P (10 µg/ml), WB (1 µg/ml), WB (1 µg/ml), |
| Gene ID | 115362 |
|---|---|
| Other Names | GBP5, GBP-TA antigen, GTP-binding protein 5, Guanylate binding protein 5, Guanylate-binding protein 5, GBP-5 |
| Target/Specificity | GBP5 antibody is predicted to not cross-react with other GBP family members. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GBP5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GBP5 {ECO:0000303|PubMed:20180847, ECO:0000312|HGNC:HGNC:19895} |
|---|---|
| Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847). Following infection, recruited to the pathogen-containing vacuoles or vacuole- escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double- stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). As an activator of NLRP3 inflammasome assembly: promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:26996307, PubMed:31091448). |
| Cellular Location | Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8CFB4}; Lipid-anchor, GPI-like-anchor. Golgi apparatus membrane; Lipid-anchor. Cytoplasm |
| Tissue Location | Expressed in peripheral blood monocytes (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Stimulates the NLRP3 inflammasome assembly upon bacterial challenge.
References
Avdalovic A.,et al.Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
Fellenberg F.,et al.J. Invest. Dermatol. 122:1510-1517(2004).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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