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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRIM24 / TIF1 Antibody (Internal)   

TRIM24 / TIF1 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - TRIM24 / TIF1 Antibody (Internal) ALS16764
    Anti-TRIM24 / TIF1 antibody IHC staining of human testis.
  • ICC - TRIM24 / TIF1 Antibody (Internal) ALS16764
    Immunocytochemistry of TRIM24 in EL4 cells with TRIM24 antibody at 2.5 ug/ml.
  • IF - TRIM24 / TIF1 Antibody (Internal) ALS16764
    Immunofluorescence of TRIM24 in EL4 cells with TRIM24 antibody at 20 ug/ml.
  • WB - TRIM24 / TIF1 Antibody (Internal) ALS16764
    Western blot analysis of TRIM24 in EL4 cell lysate with TRIM24 antibody at (A) 0.5 and (B) 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC, E
Primary Accession O15164
Other Accession 8805
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 116831 Da
Dilution ICC (2.5 µg/ml), IF (20 µg/ml), IHC-P (10 µg/ml), WB (0.5 - 2 µg/ml),
Additional Information
Gene ID 8805
Other Names TRIM24, TF1A, TIF1, TIF1A, Tripartite motif-containing 24, TIF1ALPHA, PTC6, RNF82, TIF1-alpha, Tripartite motif containing 24, HTIF1, RING finger protein 82
Target/Specificity At least two isoforms of TRIM24 are known to exist.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTRIM24 / TIF1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM24
Synonyms RNF82, TIF1, TIF1A
Function Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).
Cellular Location Nucleus. Cytoplasm. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear
Research Areas
Citations (0)

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Background

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

References

Thenot S.,et al.J. Biol. Chem. 272:12062-12068(1997).
Venturini L.,et al.Oncogene 18:1209-1217(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16764
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