|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||110462 Da|
|Dilution||IF (5 µg/ml), IHC-P (10 µg/ml), WB (1 µg/ml),|
|Other Names||ERAP2, Aminopeptidase, L-RAP, LRAP|
|Target/Specificity||ERAP2 antibody is human, mouse and rat reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||ERAP2 / Aminopeptidase Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type II membrane protein|
|Tissue Location||Ubiquitously expressed. Highly expressed in spleen and leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys.
Tanioka T.,et al.J. Biol. Chem. 278:32275-32283(2003).
Tanioka T.,et al.FEBS J. 272:916-928(2005).
Schomburg L.,et al.Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Liu T.,et al.J. Proteome Res. 4:2070-2080(2005).
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