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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   VCL / Vinculin Antibody (C-Terminus)   

VCL / Vinculin Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - VCL / Vinculin Antibody (C-Terminus) ALS16773
    Anti-VCL / Vinculin antibody IHC staining of human heart.
  • IHC-P - VCL / Vinculin Antibody (C-Terminus) ALS16773
    Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IF - VCL / Vinculin Antibody (C-Terminus) ALS16773
    Immunofluorescence of Vinculin in rat small intestine tissue with Vinculin antibody at 20 ug/ml.
  • WB - VCL / Vinculin Antibody (C-Terminus) ALS16773
    Western blot analysis of Vinculin in PC-3 cell lysate with Vinculin antibody at (A) 1 and (B) 2...
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P18206
Other Accession 7414
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 123799 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 7414
Other Names VCL, CMD1W, CMH15, Metavinculin, Vinculin, MVCL
Target/Specificity Vinculin antibody is human, mouse and rat specific. At least three isoforms of Vinculin are known to exist.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsVCL / Vinculin Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VCL
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003}; Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Note=Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. {ECO:0000250|UniProtKB:P12003}
Tissue Location Metavinculin is muscle-specific.
Research Areas
Citations (0)

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Background

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

References

Weller P.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:5667-5671(1990).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Deloukas P.,et al.Nature 429:375-381(2004).
Moiseyeva E.P.,et al.J. Biol. Chem. 268:4318-4325(1993).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.

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$ 395.00
Cat# ALS16773
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