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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   IL36RN / IL1F5 Antibody (C-Terminus)   

IL36RN / IL1F5 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - IL36RN / IL1F5 Antibody (C-Terminus) ALS16775
    Anti-IL36RN / IL1F5 antibody IHC staining of human colon.
  • IF - IL36RN / IL1F5 Antibody (C-Terminus) ALS16775
    Immunofluorescence of IL-36RN in rat small intestine tissue with IL-36RN antibody at 20 ug/ml.
  • WB - IL36RN / IL1F5 Antibody (C-Terminus) ALS16775
    Western blot analysis of IL-36RN in 3T3 cell lysate with IL-36RN antibody at 1 ug/ml in (A) the...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9UBH0
Other Accession 26525
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 16962 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 26525
Other Names IL36RN, FIL1, FIL1D, IL-1 delta, IL-1 related protein 3, IL-1HY1, IL-1RP3, IL-1-related protein 3, IL1F5, IL1RP3, IL1L1, IL36RA, Interleukin-1 delta, Family of interleukin 1-delta, FIL1 delta, IL-1L1, IL-1ra homolog 1, Interleukin-1 family member 5, ...
Target/Specificity IL-36RN antibody is human specific. At least two isoforms of IL-36RN are known to exist.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsIL36RN / IL1F5 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL36RN
Synonyms FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3
Function Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Cellular Location Secreted.
Tissue Location Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types Increased in lesional psoriasis skin
Research Areas
Citations (0)

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Background

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

References

Smith D.E.,et al.J. Biol. Chem. 275:1169-1175(2000).
Mulero J.J.,et al.Biochem. Biophys. Res. Commun. 263:702-706(1999).
Barton J.L.,et al.Eur. J. Immunol. 30:3299-3308(2000).
Debets R.,et al.J. Immunol. 167:1440-1446(2001).
Busfield S.J.,et al.Genomics 66:213-216(2000).

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$ 395.00
Cat# ALS16775
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