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MAP1LC3C / LC3C Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, E |
|---|---|
| Primary Accession | Q9BXW4 |
| Other Accession | 440738 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 16852 Da |
| Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
| Gene ID | 440738 |
|---|---|
| Other Names | MAP1LC3C, ATG8J, LC3C, MAP1A/MAP1B LC3 C, MAP1A/MAP1B light chain 3 C, LC3-like protein 2 |
| Target/Specificity | MAP1LC3C antibody is human, mouse and rat reactive. Multiple isoforms MAP1LC3C are known to exist. MAP1LC3C antibody is predicted to not cross-react with MAP1LC3A or MAP1LC3B. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MAP1LC3C / LC3C Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MAP1LC3C |
|---|---|
| Function | Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2 (PubMed:23022382). Recruits all ATG8 family members to infecting bacteria such as S.typhimurium (PubMed:23022382). May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins (PubMed:28404643). |
| Cellular Location | Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Endomembrane system; Lipid-anchor. Cytoplasm, cytoskeleton. Note=LC3-II binds to the autophagic membranes. |
| Tissue Location | Most abundant in placenta, lung and ovary. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.
References
He H.,et al.J. Biol. Chem. 278:29278-29287(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Tanida I.,et al.J. Biol. Chem. 279:36268-36276(2004).
Behrends C.,et al.Nature 466:68-76(2010).
Popovic D.,et al.Mol. Cell. Biol. 32:1733-1744(2012).
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