|Application ||WB, IHC-P, IF, E|
|Calculated MW||16852 Da|
|Dilution||IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),|
|Other Names||MAP1LC3C, ATG8J, LC3C, MAP1A/MAP1B LC3 C, MAP1A/MAP1B light chain 3 C, LC3-like protein 2|
|Target/Specificity||MAP1LC3C antibody is human, mouse and rat reactive. Multiple isoforms MAP1LC3C are known to exist. MAP1LC3C antibody is predicted to not cross-react with MAP1LC3A or MAP1LC3B.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||MAP1LC3C / LC3C Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium.|
|Cellular Location||Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome Note=LC3-II binds to the autophagic membranes|
|Tissue Location||Most abundant in placenta, lung and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium.
He H.,et al.J. Biol. Chem. 278:29278-29287(2003).
Gregory S.G.,et al.Nature 441:315-321(2006).
Tanida I.,et al.J. Biol. Chem. 279:36268-36276(2004).
Behrends C.,et al.Nature 466:68-76(2010).
Popovic D.,et al.Mol. Cell. Biol. 32:1733-1744(2012).
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