RPSA / Laminin Receptor Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
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Primary Accession | P08865 |
Other Accession | 3921 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 32854 Da |
Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
Gene ID | 3921 |
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Other Names | RPSA, 37 kDa laminin receptor, 37LRP, 40S ribosomal protein SA, 67LR, 67 kDa laminin receptor, 37/67 kDa laminin receptor, 67kD, ribosomal protein SA, LAMR1, LAMBR, Laminin receptor 1, LamR, NEM/1CHD4, SA, LRP/LR, Laminin binding protein, Laminin Rec ... |
Target/Specificity | RPSA antibody is human, mouse and rat reactive. |
Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | RPSA / Laminin Receptor Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RPSA {ECO:0000255|HAMAP-Rule:MF_03016} |
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Synonyms | LAMBR, LAMR1 |
Function | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. |
Cellular Location | Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity) Colocalizes with PPP1R16B in the cell membrane. {ECO:0000255|HAMAP- Rule:MF_03016} |
Provided below are standard protocols that you may find useful for product applications.
Background
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.
References
Yow H.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6394-6398(1988).
van den Ouweland A.M.W.,et al.Nucleic Acids Res. 17:3829-3843(1989).
Satoh K.,et al.Cancer Lett. 62:199-203(1992).
Jackers P.,et al.Oncogene 13:495-503(1996).
Shi Y.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
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