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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   RPSA / Laminin Receptor Antibody (C-Terminus)   

RPSA / Laminin Receptor Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - RPSA / Laminin Receptor Antibody (C-Terminus) ALS16785
    Anti-RPSA / Laminin Receptor antibody IHC staining of human kidney.
  • IF - RPSA / Laminin Receptor Antibody (C-Terminus) ALS16785
    Immunofluorescence of RPSA in mouse liver tissue with RPSA antibody at 20 µg/mL.
  • WB - RPSA / Laminin Receptor Antibody (C-Terminus) ALS16785
    Western blot analysis of RPSA in HepG2 cell lysate with RPSA antibody at (A) 1 and (B) 2 ug/ml.
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P08865
Other Accession 3921
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 32854 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 3921
Other Names RPSA, 37 kDa laminin receptor, 37LRP, 40S ribosomal protein SA, 67LR, 67 kDa laminin receptor, 37/67 kDa laminin receptor, 67kD, ribosomal protein SA, LAMR1, LAMBR, Laminin receptor 1, LamR, NEM/1CHD4, SA, LRP/LR, Laminin binding protein, Laminin Rec ...
Target/Specificity RPSA antibody is human, mouse and rat reactive.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsRPSA / Laminin Receptor Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RPSA {ECO:0000255|HAMAP-Rule:MF_03016}
Synonyms LAMBR, LAMR1
Function Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.
Cellular Location Cell membrane. Cytoplasm. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin- binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus (By similarity). Colocalizes with PPP1R16B in the cell membrane {ECO:0000255|HAMAP-Rule:MF_03016}
Research Areas
Citations ( 0 )

Background

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria.

References

Yow H.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6394-6398(1988).
van den Ouweland A.M.W.,et al.Nucleic Acids Res. 17:3829-3843(1989).
Satoh K.,et al.Cancer Lett. 62:199-203(1992).
Jackers P.,et al.Oncogene 13:495-503(1996).
Shi Y.,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16785
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