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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GRK6 Antibody (C-Terminus)   

GRK6 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - GRK6 Antibody (C-Terminus) ALS16787
    Anti-GRK6 antibody IHC staining of human kidney.
  • IHC - GRK6 Antibody (C-Terminus) ALS16787
    Anti-GRK6 antibody IHC staining of human colon.
  • IF - GRK6 Antibody (C-Terminus) ALS16787
    Immunofluorescence of GRK6 in human small intestine tissue with GRK6 antibody at 20 µg/mL.
  • WB - GRK6 Antibody (C-Terminus) ALS16787
    Western blot analysis of GRK6 in rat small intestine tissue lysate with GRK6 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession P43250
Other Accession 2870
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 65991 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 2870
Other Names GRK6, GPRK6
Target/Specificity GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsGRK6 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRK6
Synonyms GPRK6
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).
Cellular Location Membrane; Lipid-anchor.
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

References

Benovic J.L.,et al.J. Biol. Chem. 268:19521-19527(1993).
Premont R.T.,et al.J. Biol. Chem. 274:29381-29389(1999).
Schmutz J.,et al.Nature 431:268-274(2004).
Haribabu B.,et al.Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993).
Stoffel R.H.,et al.J. Biol. Chem. 269:27791-27794(1994).

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$ 395.00
Cat# ALS16787
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