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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   TRPV4 Antibody (Internal)   

TRPV4 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - TRPV4 Antibody (Internal) ALS16788
    Anti-TRPV4 antibody IHC staining of human heart.
  • IHC - TRPV4 Antibody (Internal) ALS16788
    Anti-TRPV4 antibody IHC staining of human adrenal.
  • IF - TRPV4 Antibody (Internal) ALS16788
    Immunofluorescence of TRPV4 in human lung tissue with TRPV4 antibody at 20 µg/mL.
  • WB - TRPV4 Antibody (Internal) ALS16788
    Western blot analysis of TRPV4 in human testis tissue lysate with TRPV4 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q9HBA0
Other Accession 59341
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 98281 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 59341
Other Names TRPV4, CMT2C, HMSN2C, OTRPC4, SSQTL1, VR-OAC, VRL-2, Osm-9-like TRP channel 4, SPSMA, TRP12, VRL2, VROAC, SMAL
Target/Specificity TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsTRPV4 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRPV4
Synonyms VRL2, VROAC
Function Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum Isoform 5: Cell membrane.
Tissue Location Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level)
Research Areas
Citations (0)

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Background

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

References

Liedtke W.B.,et al.Cell 103:525-535(2000).
Strotmann R.,et al.Nat. Cell Biol. 2:695-702(2000).
Suzuki M.,et al.J. Biol. Chem. 278:22664-22668(2003).
Ishibashi K.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Kelsell R.E.,et al.Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16788
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(40 western blots)
Availability: 5 days
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