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SUZ12 Antibody (Internal)

Rabbit Polyclonal Antibody

     
  • IHC - SUZ12 Antibody (Internal) ALS16789
    Anti-SUZ12 antibody IHC staining of human colon.
  • IF - SUZ12 Antibody (Internal) ALS16789
    Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 µg/mL.
  • WB - SUZ12 Antibody (Internal) ALS16789
    Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q15022
Other Accession 23512
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 83055 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 23512
Other Names SUZ12, ChET 9 protein, Joined to JAZF1 protein, CHET9, JJAZ1, KIAA0160, Polycomb protein SUZ12
Target/Specificity SUZ12 antibody is human specific.
Reconstitution & Storage PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsSUZ12 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SUZ12
Synonyms CHET9, JJAZ1, KIAA0160
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Cellular Location Nucleus.
Tissue Location Overexpressed in breast and colon cancer.
Citations (0)

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Background

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

References

Nagase T.,et al.DNA Res. 2:167-174(1995).
Koontz J.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:6348-6353(2001).
Weinmann A.S.,et al.Mol. Cell. Biol. 21:6820-6832(2001).
Kuzmichev A.,et al.Genes Dev. 16:2893-2905(2002).
Cao R.,et al.Science 298:1039-1043(2002).

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$ 395.00
Cat# ALS16789
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