SUZ12 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IF, E |
---|---|
Primary Accession | Q15022 |
Other Accession | 23512 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | IgG |
Calculated MW | 83055 Da |
Dilution | IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml), |
Gene ID | 23512 |
---|---|
Other Names | SUZ12, ChET 9 protein, Joined to JAZF1 protein, CHET9, JJAZ1, KIAA0160, Polycomb protein SUZ12 |
Target/Specificity | SUZ12 antibody is human specific. |
Reconstitution & Storage | PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
Precautions | SUZ12 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SUZ12 |
---|---|
Synonyms | CHET9, JJAZ1, KIAA0160 |
Function | Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12435631, PubMed:12351676, PubMed:15385962, PubMed:15099518, PubMed:15225548, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557). |
Cellular Location | Nucleus Note=Localizes to chromatin as part of the PRC2 complex |
Tissue Location | Overexpressed in breast and colon cancer. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
References
Nagase T.,et al.DNA Res. 2:167-174(1995).
Koontz J.I.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:6348-6353(2001).
Weinmann A.S.,et al.Mol. Cell. Biol. 21:6820-6832(2001).
Kuzmichev A.,et al.Genes Dev. 16:2893-2905(2002).
Cao R.,et al.Science 298:1039-1043(2002).
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