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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   FMR1 / FMRP Antibody (C-Terminus)   

FMR1 / FMRP Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - FMR1 / FMRP Antibody (C-Terminus) ALS16790
    Anti-FMR1 / FMRP antibody IHC staining of human testis.
  • IF - FMR1 / FMRP Antibody (C-Terminus) ALS16790
    Immunofluorescence of FMR1 in human brain tissue with FMR1 antibody at 20 µg/mL.
  • WB - FMR1 / FMRP Antibody (C-Terminus) ALS16790
    Western blot analysis of FMR1 in rat brain tissue lysate with FMR1 antibody at 1 ug/ml.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q06787
Other Accession 2332
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 71174 Da
Dilution IF (20 µg/ml), IHC-P (10 µg/ml), WB (1 - 2 µg/ml),
Additional Information
Gene ID 2332
Other Names FMR1, FMRP, POF, Protein FMR-1, Premature ovarian failure 1, Fragile X mental retardation 1, FRAXA, POF1
Target/Specificity FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
Reconstitution & Storage PBS, 0.02% sodium azide. Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
PrecautionsFMR1 / FMRP Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FMR1
Function Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).
Cellular Location Cytoplasm. Nucleus, nucleolus.
Tissue Location Highest levels found in neurons, brain, testis, placenta and lymphocytes. Also expressed in epithelial tissues and at very low levels in glial cells
Research Areas
Citations (0)

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Background

Translation repressor. Component of the CYFIP1-EIF4E- FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression (By similarity). RNA- binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. May play a role in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C).

References

Verkerk A.J.M.H.,et al.Cell 65:905-914(1991).
Verkerk A.J.M.H.,et al.Hum. Mol. Genet. 2:399-404(1993).
Verkerk A.J.H.M.,et al.Hum. Mol. Genet. 2:1348-1348(1993).
Corominas R.,et al.Nat. Commun. 5:3650-3650(2014).
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 395.00
Cat# ALS16790
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