|Application ||WB, IHC-P, IF, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||28467 Da|
|Dilution||IF (20 µg/ml), IHC-P (10 µg/ml), WB (0.5 - 1 µg/ml),|
|Other Names||CEBPD, C/EBP-delta, C/EBP delta, CELF, CRP3, NF-IL6-beta, Nuclear factor NF-IL6-beta|
|Target/Specificity||Human CEBPD / CEBP Delta. Multiple transcript variants encoding different isoforms have been found for this gene.|
|Reconstitution & Storage||PBS, 0.02% sodium azide. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||C/EBP Delta / CEBPD Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).|
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Provided below are standard protocols that you may find useful for product applications.
C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.
Kinoshita S.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1473-1476(1992).
Cleutjens C.B.,et al.Genomics 16:520-523(1993).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Wang J.-M.,et al.Nucleic Acids Res. 34:217-231(2006).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
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