|Application ||WB, IHC-P, IF, Flo|
|Calculated MW||36566 Da|
|Dilution||Flo (1:100), IF (1:100), IHC-P (1:50), WB (1:2000),|
|Other Names||SRR, D-serine dehydratase, ISO1, L-serine ammonia-lyase, L-serine dehydratase, ILV1, Serine racemase, D-serine ammonia-lyase|
|Target/Specificity||Human SRR / Serine Racemase|
|Reconstitution & Storage||PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.|
|Precautions||SRR / Serine Racemase Antibody (clone 9E8) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.|
|Tissue Location||Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney and liver|
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Provided below are standard protocols that you may find useful for product applications.
Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.
De Miranda J.,et al.Gene 256:183-188(2000).
Xia M.,et al.Brain Res. Mol. Brain Res. 125:96-104(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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