|Application ||IHC-P, E|
|Calculated MW||57934 Da|
|Dilution||ELISA (1:80000), IHC-P (10 µg/ml),|
|Other Names||AMIGO2, ALI1, Alivin 1, Alivin-1, Alvin 1, AMIGO-2, Amphoterin induced gene 2, Amphoterin-induced protein 2, Transmembrane protein AMIGO2, DEGA|
|Reconstitution & Storage||PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.|
|Precautions||AMIGO2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Nucleus Note=Associated with nucleus as well as plasma membrane Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).|
|Tissue Location||Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.|
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Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Kuja-Panula J.,et al.J. Cell Biol. 160:963-973(2003).
Ono T.,et al.J. Neurosci. 23:5887-5896(2003).
Rabenau K.E.,et al.Oncogene 23:5056-5067(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Olsen J.V.,et al.Cell 127:635-648(2006).
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