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AMIGO2 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - AMIGO2 Antibody (C-Terminus) ALS16801
    Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • IHC - AMIGO2 Antibody (C-Terminus) ALS16801
    Immunohistochemical staining of formalin-fixed paraffin-embedded breast carcinoma showing membrane staining with anti-AMIGO2 antibody dilution 1:100.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q86SJ2
Other Accession 347902
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 57934 Da
Dilution ELISA (1:80000), IHC-P (10 µg/ml),
Additional Information
Gene ID 347902
Other Names AMIGO2, ALI1, Alivin 1, Alivin-1, Alvin 1, AMIGO-2, Amphoterin induced gene 2, Amphoterin-induced protein 2, Transmembrane protein AMIGO2, DEGA
Reconstitution & Storage PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year.
PrecautionsAMIGO2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AMIGO2 {ECO:0000312|EMBL:AAH47595.1}
Function Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
Cellular Location Cell membrane; Single-pass type I membrane protein. Nucleus Note=Associated with nucleus as well as plasma membrane Restricted to somata of cerebellar as well as hippocampal neurons (By similarity).
Tissue Location Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
Research Areas
Citations (0)

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Background

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

References

Kuja-Panula J.,et al.J. Cell Biol. 160:963-973(2003).
Ono T.,et al.J. Neurosci. 23:5887-5896(2003).
Rabenau K.E.,et al.Oncogene 23:5056-5067(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Olsen J.V.,et al.Cell 127:635-648(2006).

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$ 395.00
Cat# ALS16801
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