Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
AMIGO2 Antibody (C-Terminus)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q86SJ2 |
| Other Accession | 347902 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 57934 Da |
| Dilution | ELISA (1:80000), IHC-P (10 µg/ml), |
| Gene ID | 347902 |
|---|---|
| Other Names | AMIGO2, ALI1, Alivin 1, Alivin-1, Alvin 1, AMIGO-2, Amphoterin induced gene 2, Amphoterin-induced protein 2, Transmembrane protein AMIGO2, DEGA |
| Reconstitution & Storage | PBS, pH 7.4, 0.02% sodium azide. Store at -20°C for up to one year. |
| Precautions | AMIGO2 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AMIGO2 {ECO:0000312|EMBL:AAH47595.1} |
|---|---|
| Function | Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Nucleus. Note=Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity) |
| Tissue Location | Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.
References
Kuja-Panula J.,et al.J. Cell Biol. 160:963-973(2003).
Ono T.,et al.J. Neurosci. 23:5887-5896(2003).
Rabenau K.E.,et al.Oncogene 23:5056-5067(2004).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Olsen J.V.,et al.Cell 127:635-648(2006).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
