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PLG / Plasmin / Plasminogen Antibody

Sheep Polyclonal Antibody

     
  • IHC - PLG / Plasmin / Plasminogen Antibody ALS16803
    Anti-PLG / Plasmin / Plasminogen antibody IHC staining of human liver.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P00747
Other Accession 5340
Reactivity Human, Mouse, Rat
Host Sheep
Clonality Polyclonal
Calculated MW 90569 Da
Dilution ELISA (10 µg/ml), IHC-P (5 µg/ml), WB (10 µg/ml),
Additional Information
Gene ID 5340
Other Names PLG, Plasmin, Plasminogen
Target/Specificity Mouse PLG / Plasmin / Plasminogen
Reconstitution & Storage 50% glycerol/H2O (vol/vol). Store at -20°C.
PrecautionsPLG / Plasmin / Plasminogen Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLG
Function Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Cellular Location Secreted. Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin Interaction with HRG tethers it to the cell surface
Tissue Location Present in plasma and many other extracellular fluids. It is synthesized in the liver
Volume 50 µl
Research Areas
Citations (0)

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Background

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

References

Petersen T.E.,et al.J. Biol. Chem. 265:6104-6111(1990).
Forsgren M.,et al.FEBS Lett. 213:254-260(1987).
Browne M.J.,et al.Submitted (OCT-1991) to the EMBL/GenBank/DDBJ databases.
Mungall A.J.,et al.Nature 425:805-811(2003).
Sottrup-Jensen L.,et al.Submitted (JUL-1977) to the PIR data bank.

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$ 395.00
Cat# ALS16803
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