|Application ||WB, IHC-P, E|
|Calculated MW||70109 Da|
|Dilution||ELISA (10 µg/ml), IHC-P (5 µg/ml), WB (10 µg/ml),|
|Other Names||F11, Coagulation factor XI, Factor xi deficiency, F11 deficiency, Factor XI, PTA deficiency, PTA, Rosenthal syndrome, FXI|
|Target/Specificity||Recognizes human Factor XI.|
|Reconstitution & Storage||ddH20, 50% glycerol. May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months.|
|Precautions||F11 / FXI / Factor XI Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.|
|Tissue Location||Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells|
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Provided below are standard protocols that you may find useful for product applications.
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Fujikawa K.,et al.Biochemistry 25:2417-2424(1986).
Asakai R.,et al.Biochemistry 26:7221-7228(1987).
Hsu T.-C.,et al.J. Biol. Chem. 273:13787-13793(1998).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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