|Application ||IHC-P, E, IE|
|Calculated MW||54306 Da|
|Dilution||IHC-P (5 µg/ml),|
|Other Names||VTN, Epibolin, Serum-spreading factor, VNT, S-protein, Somatomedin B, V75, VN, Complement S-protein, Serum spreading factor, Vitronectin|
|Target/Specificity||Specific for vitronectin as demonstrated by immunoelectrophoresis. A single precipitin arc is observed with normal plasma, of identical mobility to that obtained with purified vitronectin.|
|Reconstitution & Storage||0.01 M HEPES, pH 7.4, 0.15 M sodium chloride, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||VTN / Vitronectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.|
|Cellular Location||Secreted, extracellular space.|
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Provided below are standard protocols that you may find useful for product applications.
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Suzuki S.,et al.EMBO J. 4:2519-2524(1985).
Suzuki S.,et al.Submitted (JUN-1986) to the PIR data bank.
Jenne D.E.,et al.EMBO J. 4:3153-3157(1985).
Jenne D.E.,et al.Biochemistry 26:6735-6742(1987).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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