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SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10)

Mouse Monoclonal Antibody

     
  • IHC - SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10) ALS16807
    Anti-SERPINA1 / Alpha 1 Antitrypsin antibody IHC staining of human liver.
    detail
  • WB - SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10) ALS16807
    HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SERPINA1...
    detail
  • WB - SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10) ALS16807
    Western blot of extracts (35 ug) from 9 different cell lines by using anti-SERPINA1 monoclonal...
    detail
  •  - SERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10) ALS16807
    Immunoprecipitation(IP) of SERPINA1 by using monoclonal anti-SERPINA1 antibodies (Negative...
    detail
  • SPECIFICATION
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  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IP
Primary Accession P01009
Other Accession 5265
Reactivity Human, Monkey, Dog
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 15H10
Calculated MW 46737 Da
Dilution IHC-P (10 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 5265
Other Names SERPINA1, A1A, A1AT, AAT, Alpha 1 Antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Alpha-1-antitrypsin, Alpha1AT, PRO2275, Alpha-1-antitrypsin null, PI1, Serpin A1
Target/Specificity Human SERPINA1 / Alpha 1 Antitrypsin
Reconstitution & Storage PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsSERPINA1 / Alpha 1 Antitrypsin Antibody (clone 15H10) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SERPINA1 (HGNC:8941)
Synonyms AAT, PI
Function Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Cellular Location Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum
Tissue Location Ubiquitous. Expressed in leukocytes and plasma.
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

References

Bollen A.,et al.DNA 2:255-264(1983).
Long G.L.,et al.Biochemistry 23:4828-4837(1984).
Rosenberg S.,et al.Nature 312:77-80(1984).
Ciliberto G.,et al.Cell 41:531-540(1985).
Nukiwa T.,et al.J. Biol. Chem. 261:15989-15994(1986).

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Discontinued
Cat# ALS16807
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