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MDFI / I-MF Antibody (Internal)

Goat Polyclonal Antibody

     
  • IHC - MDFI / I-MF Antibody (Internal) ALS16812
    Anti-MDFI / I-MF antibody IHC staining of human bronchus.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q99750
Other Accession 4188
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 25029 Da
Dilution ELISA (1:16000), IHC-P (5 µg/ml),
Additional Information
Gene ID 4188
Other Names MDFI, I-MF, I-mfa, MyoD family inhibitor, Inhibitor of MyoD family a, Myogenic repressor I-mf
Target/Specificity Human MDFI.
Reconstitution & Storage Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsMDFI / I-MF Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MDFI
Function Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).
Cellular Location Nucleus. Cytoplasm
Research Areas
Citations (0)

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Background

Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity).

References

Kraut N.,et al.Mamm. Genome 8:618-619(1997).
Mungall A.J.,et al.Nature 425:805-811(2003).

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$ 395.00
Cat# ALS16812
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