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>   home   >   Products   >   Primary Antibodies   >   DOC2A Antibody (aa233-246)   

DOC2A Antibody (aa233-246)

Goat Polyclonal Antibody

     
  • IHC - DOC2A Antibody (aa233-246) ALS16814
    Anti-DOC2A antibody IHC staining of human brain, cortex.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q14183
Other Accession 8448
Reactivity Human
Host Goat
Clonality Polyclonal
Calculated MW 43959 Da
Dilution ELISA (1:16000), IHC-P (5 µg/ml),
Additional Information
Gene ID 8448
Other Names DOC2A, DOC2, Doc2-alpha, Double C2-like domains, alpha
Target/Specificity Human DOC2A.
Reconstitution & Storage Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing.
PrecautionsDOC2A Antibody (aa233-246) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DOC2A
Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Cellular Location Lysosome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles
Tissue Location Predominantly expressed in brain. Also expressed in testis.
Citations (0)

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Background

Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.

References

Orita S.,et al.Biochem. Biophys. Res. Commun. 206:439-448(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Sakaguchi G.,et al.Biochem. Biophys. Res. Commun. 217:1053-1061(1995).
Mochida S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:11418-11422(1998).

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$ 395.00
Cat# ALS16814
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