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CSNK1A1 / CK1 Alpha Antibody

Chicken Polyclonal Antibody

     
  • IHC - CSNK1A1 / CK1 Alpha Antibody ALS16817
    Anti-CSNK1A1 / CK1 Alpha antibody IHC staining of human small intestine.
  • ICC - CSNK1A1 / CK1 Alpha Antibody ALS16817
    High power image of HeLa cells stained with chicken casein kinase 1 alpha antibody (red) and our...
  • WB - CSNK1A1 / CK1 Alpha Antibody ALS16817
    Western blot of whole rat spinal cord homogenate stained with chicken casein kinase 1 alpha...
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, ICC
Primary Accession P48729
Other Accession 1452
Reactivity Human
Host Chicken
Clonality Polyclonal
Isotype IgY
Calculated MW 38915 Da
Dilution ICC (1:5000), IF (1:500 - 1:1000), IHC-P (1:500), WB (1:10000),
Additional Information
Gene ID 1452
Other Names CSNK1A1, CK1 alpha, CK1a, CK1alpha, Clock regulator kinase, CK1, Casein kinase 1 alpha, CKIa, CKIalpha, Down-regulated in lung cancer, HLCDGP1, PRO2975, Casein kinase 1, alpha 1, Casein kinase I alpha, Casein kinase I isoform alpha, CKI-alpha
Reconstitution & Storage Liquid. +4°C or -20°C, Avoid repeated freezing and thawing.
PrecautionsCSNK1A1 / CK1 Alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CSNK1A1
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688)
Volume 50 µl
Research Areas
Citations (0)

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Background

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.

References

Tapia C.,et al.FEBS Lett. 349:307-312(1994).
Fish K.J.,et al.J. Biol. Chem. 270:14875-14883(1995).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

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$ 395.00
Cat# ALS16817
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