|Application ||WB, IHC-P, IF, ICC|
|Calculated MW||38915 Da|
|Dilution||ICC (1:5000), IF (1:500 - 1:1000), IHC-P (1:500), WB (1:10000),|
|Other Names||CSNK1A1, CK1 alpha, CK1a, CK1alpha, Clock regulator kinase, CK1, Casein kinase 1 alpha, CKIa, CKIalpha, Down-regulated in lung cancer, HLCDGP1, PRO2975, Casein kinase 1, alpha 1, Casein kinase I alpha, Casein kinase I isoform alpha, CKI-alpha|
|Reconstitution & Storage||Liquid. +4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||CSNK1A1 / CK1 Alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688)|
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Provided below are standard protocols that you may find useful for product applications.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.
Tapia C.,et al.FEBS Lett. 349:307-312(1994).
Fish K.J.,et al.J. Biol. Chem. 270:14875-14883(1995).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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