|Application ||WB, IHC-P, IF, ICC|
|Calculated MW||38915 Da|
|Dilution||ICC (1:5000), IF (1:500 - 1:1000), IHC-P (1:500), WB (1:10000),|
|Other Names||CSNK1A1, CK1 alpha, CK1a, CK1alpha, Clock regulator kinase, CK1, Casein kinase 1 alpha, CKIa, CKIalpha, Down-regulated in lung cancer, HLCDGP1, PRO2975, Casein kinase 1, alpha 1, Casein kinase I alpha, Casein kinase I isoform alpha, CKI-alpha|
|Reconstitution & Storage||Liquid. +4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||CSNK1A1 / CK1 Alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis.
Tapia C.,et al.FEBS Lett. 349:307-312(1994).
Fish K.J.,et al.J. Biol. Chem. 270:14875-14883(1995).
Wan D.,et al.Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.