|Application ||WB, IHC-P, IF, ICC|
|Reactivity||Human, Mouse, Rat, Bovine|
|Calculated MW||42784 Da|
|Dilution||ICC (1:500 - 1:1000), IF (1:500 - 1:1000), IHC-P (10 µg/ml), WB (1:1000 - 1:2000),|
|Other Names||RBFOX1, A2BP1, 2BP1, Ataxin 2-binding protein 1, A2BP, FOX-1, FOX1, Ataxin-2-binding protein 1, Fox-1 homolog A, HRNBP1|
|Target/Specificity||Clone 1G10 is known to react with Fox1 from human, cow, mouse and rat. Since Fox1 is highly conserved, it is likely that the antibody is effective on other species also.|
|Reconstitution & Storage||PBS, 10 mM sodium azide. +4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||RBFOX1 / A2BP1 Antibody (clone 1G10) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||A2BP, A2BP1, FOX1, HRNBP1|
|Function||RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.|
|Cellular Location||Nucleus. Cytoplasm|
|Tissue Location||Predominantly expressed in muscle and brain.|
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Provided below are standard protocols that you may find useful for product applications.
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Shibata H.,et al.Hum. Mol. Genet. 9:1303-1313(2000).
Chen W.,et al.Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Yu L.,et al.Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
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