|Application ||WB, IHC-P, IF, ICC|
|Calculated MW||51026 Da|
|Dilution||ICC (1:5000), IF (1:500 - 1:1000), IHC-P (1:100), WB (1:20000),|
|Other Names||CORO1A, Clipin-A, Coronin-like protein A, Coronin-like protein p57, CLIPINA, Coronin-1, Coronin-1A, HCORO1, p57, TACO, CLABP, CORO1|
|Target/Specificity||Human CORO1A / p57|
|Reconstitution & Storage||Antiserum. +4°C or -20°C, Avoid repeated freezing and thawing.|
|Precautions||CORO1A / Coronin 1a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).|
|Tissue Location||Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut|
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May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Suzuki K.,et al.FEBS Lett. 364:283-288(1995).
Grogan A.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
Liau G.,et al.Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
Kohchi C.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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