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Fibulin-3 / EFEMP1 Antibody (clone 1D9)
Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC |
|---|---|
| Primary Accession | Q12805 |
| Other Accession | 2202 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 1D9 |
| Calculated MW | 54641 Da |
| Dilution | Flo (1:100), IHC-P (10 µg/ml), WB (1:200 - 1:500), |
| Gene ID | 2202 |
|---|---|
| Other Names | EFEMP1, DHRD, Extracellular protein S1-5, FBNL, FBLN3, Fibrillin-like protein, Fibrillin-like, MLVT, S1-5, MTLV, DRAD, FIBL-3, Fibulin-3 |
| Target/Specificity | Human Fibulin-3 / EFEMP1 |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide. Store at -20°C. Minimize freezing and thawing. |
| Precautions | Fibulin-3 / EFEMP1 Antibody (clone 1D9) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EFEMP1 |
|---|---|
| Synonyms | FBLN3, FBNL |
| Function | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
| Cellular Location | Secreted, extracellular space. Secreted, extracellular space, extracellular matrix Note=Localizes to the lamina propria underneath the olfactory epithelium. |
| Tissue Location | In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina |
| Volume | 50 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.
References
Lecka-Czernik B.,et al.Mol. Cell. Biol. 15:120-128(1995).
Ikegawa S.,et al.Genomics 35:590-592(1996).
Giltay R.,et al.Matrix Biol. 18:469-480(1999).
Sauer C.G.,et al.Ophthalmic Genet. 22:27-34(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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