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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   FZD5 / Frizzled 5 Antibody (aa461-510)   

FZD5 / Frizzled 5 Antibody (aa461-510)

Rabbit Polyclonal Antibody

     
  • IHC - FZD5 / Frizzled 5 Antibody (aa461-510) ALS16839
    Anti-FZD5 / Frizzled 5 antibody IHC staining of human small intestine.
  • IHC - FZD5 / Frizzled 5 Antibody (aa461-510) ALS16839
    Anti-FZD5 / Frizzled 5 antibody IHC staining of human tonsil.
  • IF - FZD5 / Frizzled 5 Antibody (aa461-510) ALS16839
    Immunofluorescence of A549 cells, using FZD5 Antibody.
  • WB - FZD5 / Frizzled 5 Antibody (aa461-510) ALS16839
    Western blot of extracts from LOVO cells, using FZD5 Antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF, E
Primary Accession Q13467
Other Accession 7855
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Calculated MW 64507 Da
Dilution ELISA (1:20000), IF (1:100 - 1:500), IHC-P (5 µg/ml), WB (1:500 - 1:1000),
Additional Information
Gene ID 7855
Other Names FZD5, C2orf31, DKFZP434E2135, Frizzled family receptor 5, Fz5, Fzd-5, FzE5, Frizzled 5, Frizzled-5, Wnt receptor, Fz-5, HFZ5
Target/Specificity FZD5 Antibody detects endogenous levels of total FZD5 protein.
Reconstitution & Storage PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol. Store at -20°C for up to one year.
PrecautionsFZD5 / Frizzled 5 Antibody (aa461-510) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD5
Synonyms C2orf31
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway.
Cellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein Note=Localized at the plasma membrane and also found at the Golgi
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway.

References

Wang Y.,et al.J. Biol. Chem. 271:4468-4476(1996).
Saitoh T.,et al.Int. J. Oncol. 19:105-110(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Tanaka S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998).

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$ 395.00
Cat# ALS16839
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